You adjust the screws to make the engine run ok. If the engine is running ok, the screws must be adjusted correctly!
When the engine is running and warmed up, screw in the throttle stop screw to give a fast tick over. Then adjust the air screw to get the engine to run as fast and cleanly as you can. Then back off the throttle stop screw and carefully adjust the mixture screw to give the smoothest running of the engine.
The mixture screw only affects tick over and low revs. The mixture at higher revs is changed by needle position, main jet size and slide cut away.